Four granule populations as volume: move the sliders and the budget, per-compartment readouts, and release fractions follow.
Total granule volume
29.5 um3 0.96 to 180 um3 across the sourced ranges. No sourced capacity for this quantity, so the bar places this cell between the smallest and the largest the sourced ranges allow, on a log scale.
Sphere-volume sum over the four granule compartments. This is what the neutrophil carries into an infection site and spends on degranulation.
source 1source 2,
Azurophilic compartment volume
22.6 um3
0.707 to 153 um3 propagated
Specific compartment volume
5.65 um3
0.214 to 20.1 um3 propagated
Gelatinase compartment volume
1.15 um3
0.036 to 6.7 um3 propagated
Secretory vesicle compartment volume
0.107 um3
0.003 to 0.724 um3 propagated
Total granule volume
29.5 um3
29.5 to 29.5 um3 propagated
Azurophilic fraction of granule volume
76.6 %
76.6 to 76.6 % propagated
Mobilisation-first fraction
4.26 %
4.26 to 4.26 % propagated
Withheld
Granule protein density (g per mL)
No sourced measured value for total granule protein concentration in human neutrophils; Lominadze 2005 gives a proteomics catalogue but not a bulk density
Degranulation half-time (seconds)
No sourced value for the half-time of individual compartment release in intact human neutrophils under physiological activation; cell-free kinetics do not map to the intact cell