granulocyte digital twin

Granule budget twin

Inputs

Azurophilic granule count 200

50 to 400 · human, marrow and blood neutrophils · electron microscopy · Bainton DF et al. 1971, J Exp Med · source

200 per cell from Bainton 1971 TEM; slider default matches twin-body count; range is parametric above and below the sourced value

Azurophilic granule radius 0.3 um

0.15 to 0.45 um · human, marrow and blood neutrophils · electron microscopy · Bainton DF et al. 1971, J Exp Med · source

azurophilic granules are the largest compartment; range thin from abstract

Specific granule count 400

100 to 600 · human neutrophil · review · Faurschou M, Borregaard N 2003, Microbes Infect · source

approximately 400 per cell; specific granules are the most numerous compartment; slider default matches twin-body count; range is parametric above and below the sourced value

Specific granule radius 0.15 um

0.08 to 0.2 um · human, marrow and blood neutrophils · electron microscopy · Bainton DF et al. 1971, J Exp Med · source

smaller than azurophilic granules; range thin from abstract

Gelatinase granule count 100

25 to 200 · human neutrophil · review · Faurschou M, Borregaard N 2003, Microbes Infect · source

approximately 100 per cell; formed last in maturation; slider default matches twin-body count; range is parametric above and below the sourced value

Gelatinase granule radius 0.14 um

0.07 to 0.2 um · human neutrophil · review · Faurschou M, Borregaard N 2003, Microbes Infect · source

similar size to specific granules; thin from abstract

Secretory vesicle count 50

10 to 100 · human neutrophil · review · Faurschou M, Borregaard N 2003, Microbes Infect · source

approximately 50 per cell; smallest and most easily released compartment; slider default matches twin-body count; range is parametric above and below the sourced value

Venule inner diameter 30 um

20 to 40 um · mouse cremaster venule · intravital fluorescence microscopy · Li YT et al. 2019, eLife · source

Vessels of 20 to 40 um in diameter observed during neutrophil rolling and arrest in mouse cremaster muscle (Li 2019, Methods). Default 30 um is the midpoint. Human post-capillary venule range is analogous; thin: species is mouse, not direct human measurement.

Secretory vesicle radius 0.08 um

0.04 to 0.12 um · human neutrophil · review · Faurschou M, Borregaard N 2003, Microbes Infect · source

secretory vesicles are the smallest compartment; thin from abstract

Sources

Borregaard N. Neutrophils, from marrow to microbes. Immunity 2010

human neutrophil · review

Faurschou M, Borregaard N. Neutrophil granules and secretory vesicles in inflammation. Microbes Infect 2003

human neutrophil · review

Bainton DF et al. The development of neutrophilic polymorphonuclear leukocytes in human bone marrow. J Exp Med 1971

human, marrow and blood neutrophils · electron microscopy

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Four granule populations as volume: move the sliders and the budget, per-compartment readouts, and release fractions follow.

Total granule volume

29.5 um3

0.96 to 180 um3 across the sourced ranges. No sourced capacity for this quantity, so the bar places this cell between the smallest and the largest the sourced ranges allow, on a log scale.

Sphere-volume sum over the four granule compartments. This is what the neutrophil carries into an infection site and spends on degranulation.

source 1 source 2,

Readouts

Azurophilic compartment volume

22.6 um3

0.707 to 153 um3 propagated

human neutrophil · sphere-volume geometry on sourced ranges · source 1