Signaling

Endoplasmic Reticulum Stress, Redox Signaling, and Neutrophil Effector Functions in Chronic Lung Diseases: Evidence and . Park SB, Yook TH, Rashid MMU et al.. Free Radic Biol Med 2026.

Dishevelled 2 coordinates aortic Notch signaling through primitive myeloid and hemogenic endothelial cells during hemato. Carpenter KA, Ide AD, Jacobs J et al.. bioRxiv 2026.

The use of anti-IL-5 in eosinophilic gastrointestinal disorders (EGIDs); a systematic review.. Elsaid M, Elsebaie MAT, Aziz MM et al.. Arab J Gastroenterol 2026.

Eosinophil-driven immunopathology exacerbates SARS-CoV-2 pneumonia in an OVA-induced airway allergy mouse model.. Iketani T, Iwata-Yoshikawa N, Sakai Y et al.. mSphere 2026.

An Oral Nanozyme Microsupplement Converts Pathological ROS Into a Colon-Adhesive Shield for Long-Term Neutrophil-Directe. Yu X, Yu X, Yan Z et al.. Adv Mater 2026.

Successful early pregnancy depends on coordinated interactions between the placenta and maternal immune cells, but the mechanisms underlying this interplay remain incompletely understood..

Surgical stress, such as liver ischemia/reperfusion (I/R) injury characterized by robust neutrophil infiltration and immune activation, induces sterile inflammation that reshapes tissue immunity and.

Mycoplasma pneumoniae pneumonia (MPP) can cause serious extrapulmonary complications, including life-threatening thrombosis. This study aimed to elucidate the roles of neutrophils and neutrophil.

PURPOSE: There is a growing need for rapid, simple, and cost-effective biomarkers that facilitate early risk stratification in patients with severe upper urinary tract infections. This study aimed to.

OBJECTIVES: Associations between carbohydrate and fiber intake and endometriosis (EM) have been inconsistent, and no study has evaluated the combined effect of the carbohydrate-to-fiber ratio (CFR).

The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) is a composite biomarker reflecting systemic inflammation and lipid metabolism. We examined associations between NHR and.

Atopic dermatitis (AD) is driven by complex interactions between keratinocytes and immune cells. In this issue of Cell Chemical Biology, Shao et al. 1 identify that NAT10-dependent ac4C modification.

Type I interferon receptor (IFNAR1) drives a conserved iron homeostasis circuit that sustains neutrophil pathogenicity across mucosal tissues; single-cell transcriptomics and CRISPR screen identify mitochondrial iron handling as the downstream mechanism; targeting selectively dampens pathogenic function without compromising antimicrobial activity.

Case report: positive basophil activation test (BAT) with sevoflurane in a patient with repeated perioperative reactions; demonstrates BAT utility for volatile anaesthetic allergy.

Fibromyalgia (FM) may involve systemic abnormalities in addition to its characteristic nociplastic pain features. This study aimed to investigate the association between routinely available.

Early prediction of acute pancreatitis (AP) severity is critical for improving outcomes. This study evaluated the diagnostic value of white blood cell (WBC) count, neutrophil count,.

(1) Background/Objective: Routine blood tests may provide useful information at different stages of epithelial ovarian cancer (EOC) management. This study evaluated continuous lactate dehydrogenase.

BACKGROUND: Heterogeneous circulating tumor cell (CTC) clusters interact with platelets, neutrophils, stromal cells, and immune cells, forming a protective state that may facilitate survival in the.

Hogan et al. on single-cell profiling of granulocytes in atopic disease.

Shin et al. show that viral-pattern-activated nasal fibroblasts secrete chemokines that recruit eosinophils in chronic rhinosinusitis with nasal polyps.

OBJECTIVE: The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and triglyceride-glucose (TyG) index are used to evaluate the risk of coronary artery disease (CAD) or chronic.

BACKGROUND: Pseudomonas aeruginosa pneumonia triggers a complex, dynamic host response, yet the cellular coordination of inflammation and repair remains poorly defined. METHODS: We performed.

OBJECTIVE: To characterize early systemic immune-inflammatory alterations after acute spinal cord injury (SCI), evaluate their association with 12-month neurological outcomes, and develop an.

Background/Objectives : Major hepatobiliary surgery elicits substantial inflammatory and catabolic stress, which may be aggravated by prolonged preoperative fasting. We evaluated the association of.

Suzuki et al. show that monomeric hapten terminates IgE-triggered calcium entry by breaking the STIM1-Orai1 channel complex in basophil-like cells; early mechanistic data.

BACKGROUND: Kawasaki disease (KD) is associated with long-term vascular sequelae, including persistent endothelial abnormalities. Data on laboratory-based markers of oxidative stress during long-term.

INTRODUCTION: Porphyromonas gingivalis (Pg) is a keystone periodontal pathogen linked to adverse pregnancy outcomes that releases outer membrane vesicles (OMV) capable of modulating innate immune.

INTRODUCTION: Successful reperfusion after endovascular thrombectomy (EVT) does not guarantee recovery. Malignant cerebral oedema (MCE) complicates approximately one in eight patients, and static.

Eosinophilic sialodochitis (ES) is a rare, allergy-associated ductal disease of the major salivary glands characterized by recurrent swelling and eosinophil-rich ductal inflammation. We describe a.

The interplay between neutrophils and macrophages is central to inflammatory regulation, yet how macrophage polarization governs the homeostasis of neutrophil extracellular traps (NETs) remains.

OBJECTIVE: Pulmonary nodules (PN) represent a clinically heterogeneous pathway that includes benign lesions, adenocarcinoma-spectrum lesions, and cases that may differ from clinically overt lung.

OBJECTIVE: This study aims to explore the associations of nine common composite inflammatory indices with hemorrhagic transformation (HT), unfavorable outcome, and all-cause mortality in patients.

BACKGROUND: Differences in gene expression between inflammatory-like (iEOS-like) and resident-like (rEOS-like) eosinophil subtypes, and in eosinophil-derived serum mediators, may reflect eosinophil.

Systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are surrogate markers of the systemic immune-inflammatory response proposed as.

Review: NETs are web-like DNA-histone-granule protein structures released by activated neutrophils; play host defense and pathological roles in bacterial infections. Discusses mechanisms and therapeutic targeting strategies.

Background: Cholangiocarcinoma (CCA) frequently recurs after curative-intent resection. Metabolic alterations and systemic inflammation may contribute to aggressive disease, but their combined.

OBJECTIVE: The value of composite inflammatory indicators in identifying sarcopenia in patients with type 2 diabetes mellitus (T2DM) remains unclear. This study investigated associations between ten.

Oral squamous cell carcinoma (OSCC) prognosis remains limited by TNM staging alone. We conducted a systematic review and meta-analysis to evaluate preoperative neutrophil-to-lymphocyte (NLR),.

This study aimed to characterize the modulation in immune cell subpopulations in murine lungs following influenza A virus (IAV) infection, assessing the effects of infectious dose, viral adaptation,.

BACKGROUND: Pulmonary embolism (PE) remains a major cause of cardiovascular morbidity and mortality. The neutrophil-to-lymphocyte ratio (NLR) is a readily available biomarker reflecting inflammatory.

Xu et al. review how mitochondrial reprogramming shapes NETs in COPD and asthma.

BACKGROUND: Systemic inflammatory response syndrome (SIRS) is a significant postoperative complication in older patients leading to higher morbidity and mortality rates. This study investigates the.

Koenis et al. report that erythroblast lipid mediators shape neutrophil development; single study.

Fibrin deposits drive NETosis; platelet GPVI receptor is the upstream signal. Hyperglycemia exacerbates the pathway independently of diabetes diagnosis. Mechanistic study.

Almas et al. review of eosinophil granule release routes, including piecemeal degranulation.

Neutrophils are central effectors of the innate immune system, providing rapid responses to harmful stimuli and contributing to both host defense and resolution of inflammation. Among their effector.

Li et al. PAD4-deficient neutrophils cannot form NETs, and the mice are more susceptible to bacterial infection.

Kouro and Takatsu review IL-5 and its receptor as the central axis of eosinophil production and survival.

Sokol et al. basophils respond to a protease allergen and help initiate Th2 responses in mice.

Ley et al. review of capture, rolling, arrest, crawling, and transmigration.

Iwasaki and Akashi map the progenitor steps from stem cell to granulocyte lineages.

Kraft and Kinet review of the high-affinity IgE receptor and its signaling in basophils and mast cells.

Segal review of the NADPH oxidase and how the phagocytic vacuole kills microbes.

Hayashi et al. human neutrophils express functional TLRs that modulate their responses.

Jose et al. discovery of eotaxin as a selective eosinophil chemoattractant.