Medications

Growing evidence highlights the central role of inflammation in the onset and progression of DKD. In this study, we investigate the association between the neutrophil percentage-to-albumin ratio.

Neutrophil Extracellular Trap-Mimetic DNA Nets Enable Concurrent Bacteria-Targeted Eradication and Toxin Neutralization.. Li J, Yang H, Lai S et al.. Angew Chem Int Ed Engl 2026.

Early dynamics of a neutrophil interferon program drive immunotherapy resistance and limit durable anti-tumor immunity.. Gao Y, Anning E, Wang L et al.. bioRxiv 2026.

Clinical Trial: Dupilumab Improves Eosinophilic Oesophagitis Outcomes Versus Placebo Regardless of Comorbidities or Trea. Dellon ES, Rothenberg ME, Spergel JM et al.. Aliment Pharmacol Ther 2026.

Hypereosinophilia With Organ Damage Secondary to Dupilumab Therapy: A Case Report and Literature Review.. Alotaibi M, AlHelal S, Alotaibi N et al.. Case Rep Dermatol Med 2026.

Algorithms in Allergy: Treatment of Hypereosinophilic Syndromes, 2026 Update.. Lefèvre G, Roufosse F, Emmi G et al.. Allergy 2026.

Predicting Non-Target Neutrophil Collection During HPC(A): Implications for Research Protocols in Apheresis.. Castillo-Aleman YM, Villegas-Valverde CA, Ventura-Carmenate Y et al.. J Clin Apher 2026.

Treatment Modalities and the Impact of Granulocyte Colony-Stimulating Factor in AML Patients Treated With Venetoclax and. Lapierre L, Laemmel L, Bérard E et al.. Clin Lymphoma Myeloma Leuk 2026.

STING reprogramming by estrogen promotes neutrophil extracellular trap formation and sex-biased resistance to ADC therap. Yan J, Zhou T, Shi S et al.. Cell 2026.

Dupilumab improves long-term asthma control in German patients with severe asthma: Real-world data. Renner A, Stoshikj S, Hamelmann E et al.. Allergol Select 2026.

Parasite-Derived IL-33 Inhibitors Prevent Bleomycin-Induced Lung Fibrosis. Carmine SD, Frangova T, Hodge SH et al.. Eur J Immunol 2026.

Severe steroid-refractory immune checkpoint inhibitor-associated pneumonitis and exploration of potential biomarkers: A . Xue YJ, Xu AZ, Yin XD et al.. Exp Ther Med 2026.

Comparative clinical efficacy and immunological modulation of subcutaneous vs. sublingual allergen immunotherapy in chil. Zeng C, Yan H, Xu H et al.. Front Med (Lausanne) 2026.

Chronic Spontaneous Urticaria Endotypes: Exploratory Proteomic Analysis in the Benralizumab ARROYO Study. Rodríguez-Suárez E, Cardner M, Muthas D et al.. Clin Exp Allergy 2026.

In vitro diagnostics of drug hypersensitivity reactions. Möbs C, Hermann Lang SC, Härtel V et al.. Allergol Select 2026.

Immune-mediated drug reaction to indocyanine green: a red light for a green dye. Toscano A, Ebo DG, Beyens M et al.. Eur Ann Allergy Clin Immunol 2026.

Hypersensitivity Reactions to Biologics: Advances in Diagnosis and Management. Yang BC. Curr Allergy Asthma Rep 2026.

Secondary pulmonary alveolar proteinosis mimicking progression of interstitial lung disease during treatment for adult-o. Yamane T, Fujita T, Onoe A et al.. Medicine (Baltimore) 2026.

Febrile neutropenia in adults with diffuse large B-cell lymphoma receiving first-line R-CHOP-based therapy: a systematic. Reyes J, Reyes A. Support Care Cancer 2026.

Case Report: PRaG 3.0 therapy for advanced cervical cancer with severe comorbidities. Gu X, Xu M, Dai J et al.. Front Oncol 2026.

Neutrophil recovery characteristics in patients with severe antithyroid drug-induced agranulocytosis: A 12-year retrospe. Luo Y, Fan X, Yang Q et al.. Endocrine 2026.

Case Report: Life-threatening neutropenia with absolute neutrophil count of zero after low-dose regional arterial infusi. Wang Y, Liu Q, Feng Y et al.. Front Oncol 2026.

A case report on the management of sepsis complicated by eroded mixed hemorrhoids following breast cancer chemotherapy. Ye Z, Xie H, Lan X et al.. Medicine (Baltimore) 2026.

OBJECTIVE: This study aimed to investigate the associations of serum cold-inducible RNA-binding protein (CIRP) and C-X-C motif chemokine ligand 5 (CXCL5) with prognosis in children with Mycoplasma.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous respiratory disorder driven by neutrophilic and eosinophilic inflammation, structural changes, and airflow limitation..

Neutrophil extracellular traps (NETs) are web‑like structures composed of decondensed chromatin and granular proteins. Initially identified as an antimicrobial defense mechanism, NETs have now.

Asthma and chronic obstructive pulmonary disease (COPD) are highly heterogeneous airway disorders that cannot be adequately understood or managed as single disease entities. Instead, both encompass a.

PURPOSE: Angiostrongylus cantonensis is a major cause of eosinophilic meningitis in Southeast Asia, but clinical data from northern Vietnam remain limited. We describe the clinical spectrum,.

OBJECTIVES: The pathogenesis of relapses in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) remains ill defined. We aimed to identify whether there are any.

A key determinant of antibiotic dose selection is the pharmacokinetic/pharmacodynamic (PK/PD) target, typically determined using dose fractionation studies in preclinical infection models. However,.

Harman et al. identify baseline blood eosinophil count and nasal polyp comorbidity as the strongest predictors of response to anti-IL-5 biologics in severe asthma.

This study aimed to construct an artificial neural network (ANN) diagnostic model for rheumatoid arthritis (RA) based on a neutrophil inflammation- and cell death-associated gene signature derived.

PURPOSE OF REVIEW: Type 2-low (T2-low) asthma, characterized by low blood and sputum eosinophils and low fractional exhaled nitric oxide (FeNO), remains a major unmet need because of frequent.

The acidic tumor microenvironment (pH 6.3-7.1) influences immune cell function, yet its impact on antibody-mediated killing remains poorly understood. While natural killer (NK) cells lose their.

Bronchoalveolar lavage fluid (BALF) is the most directly accessible sampling matrix for studying lower airway inflammation, yet conventional analyses rely on single-marker flow cytometry combined.

BACKGROUND: Pediatric idiopathic uveitis is a potentially vision-threatening inflammatory condition with limited available laboratory biomarkers for disease monitoring. Complete blood count.

Eosinophil associated diseases (EAD) are heterogeneous disorders characterized by increased and/or activated eosinophils in blood or tissues, with potential involvement of the respiratory, cutaneous,.

Invasive fungal diseases (IFDs) are associated with substantial morbidity and mortality. Neutrophil extracellular traps (NETs) are a key effector mechanism of innate antifungal immunity, but they may.

Dupilumab reduced eosinophilic otitis media severity over 12 months in severe eosinophilic asthma with nasal polyps; bronchiectasis comorbidity did not blunt the response.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder with diverse inflammatory profiles. Long-term oxygen therapy (LTOT) identifies a subgroup of patients with.

Bacterial pneumonia remains a major cause of infectious mortality, and antimicrobial resistance has intensified interest in host-directed therapy (HDT). Recent bronchoalveolar lavage fluid (BALF) and.

INTRODUCTION: Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women, and resistance to chemotherapy remains a major clinical challenge. Although.

INTRODUCTION: Hepatic alveolar echinococcosis (HAE), a lethal chronic helminth infection caused by Echinococcus multilocularis, is characterized by pronounced local immune evasion and progressive.

A growing number of biologics are approved or in development for the treatment of chronic obstructive pulmonary disease (COPD). Many reduce acute exacerbations of COPD (AECOPD), particularly among.

Sciurba et al. NEJM trial of tozorakimab (anti-IL-33) in COPD; IL-33 drives both eosinophilic and neutrophilic airway inflammation.

Campisi et al. pilot study of mepolizumab on mucus plugs in severe eosinophilic asthma, with and without bronchiectasis.

Asthma and chronic obstructive pulmonary disease (COPD) are the most prevalent chronic inflammatory airway diseases and constitute a substantial global health burden. Neutrophils are key effector.

Basophils, the rarest type of granulocytes in peripheral blood, have emerged as important orchestrators of type 2 immune responses, including allergic inflammation. They were long considered merely.

Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease of the esophagus in which symptoms, histologic activity, endoscopic severity, epithelial dysfunction, and fibrostenotic remodeling.

BACKGROUND: Pulmonary mucormycosis is a life-threatening fungal infection with a mortality rate exceeding 50%, and diabetes mellitus is one of its strongest risk factors. However, the molecular.

Approximately 15% of the population in developed countries report a penicillin allergy in their medical history. However, this changes considerably following a comprehensive allergological.

Ischemia-reperfusion injury (IRI) is a common form of tissue injury encountered in myocardial infarction, ischemic stroke, solid-organ transplantation, and complex vascular surgery. Timely.

In total, 37-39% of prepubertal patients present with cancer cells in their testes at the time of diagnosing a hematologic malignancy, and elimination of cancer cells from immature testicular tissue.

BACKGROUND AND AIMS: Despite the importance of eosinophils in histologic scoring systems of ulcerative colitis (UC), the impact of advanced therapies on eosinophils is poorly understood..

Severe obesity is linked to metabolic dysfunction-associated steatotic liver disease (MASLD), which can progress to metabolic dysfunction-associated steatohepatitis (MASH) and advanced fibrosis..

Seminal plasma (SP) is a complex immune modulator within the female reproductive tract of several species. In sheep, it can restore the fertility of cryopreserved sperm and is necessary for the.

During systemic inflammation, neutrophil extracellular traps (NETs) capture pathogens but, in the long-term, can cause bystander damage to the vasculature. Another hallmark of sepsis in the blood is.

Staphylococcus aureus ( S. aureus ), a primary exacerbating factor in eczema, remains a prevalent pathogenic public-health threat. The mechanism of mast cell/basophil degranulation in the context of.

BACKGROUND: Human ischemic stroke thrombi are increasingly recognized as biologically active immunothrombotic structures. While the NLRP3 inflammasome contributes to experimental stroke pathology,.

Asthma remains the commonest chronic pediatric respiratory disease and a major cause of childhood morbidity worldwide. Recent advances in pediatric asthma management shift the focus from symptom.

Neutrophil extracellular trap (NET), as an important effector mechanism of innate immunity, plays a critical regulatory role in various pulmonary diseases, including coronavirus disease-associated.

Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome is a disease concept characterized by UBA1 mutation that was first proposed in 2020. We report an autopsy case of VEXAS.

BACKGROUND: Vitiligo is a chronic inflammatory depigmenting skin disorder characterized by progressive loss of functional melanocytes, in which adaptive immune mechanisms, particularly.

Leishmaniases are a group of neglected tropical diseases caused by Leishmania parasites which virulence mainly relies on its modulation of the host immune response. Neutrophils, the first recruited.

Vaccines delivered via the nasal route have attracted increasing attention for their capacity to engage the mucosal immune system at the primary site of pathogen entry. However, the early innate.

Obesity is a major risk factor for metabolic syndrome, cancer, diabetes, and other diseases. The occurrence of comorbidities is associated with systemic and adipose tissue inflammation, which is.

BACKGROUND: Spontaneous bacterial peritonitis (SBP) is a severe complication of cirrhosis requiring immediate empirical antibiotic therapy. Third-generation cephalosporins are the traditional agents.

Acute respiratory distress syndrome (ARDS) may remain regionally permeable and poorly reparative after the initiating insult has weakened. We propose that, in a biologically enriched subset of.

INTRODUCTION: Neutrophil extracellular traps (NETs) are chromatin-based structures released by activated neutrophils that are associated with microvascular thrombosis and pulmonary inflammation..

Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by type 2 inflammation, including M2 macrophage infiltration. Baicalein is a flavonoid with anti-inflammatory.

Extraintestinal pathogenic Escherichia coli (ExPEC) is among the bacterial pathogens associated with infections of the female and male reproductive tracts, where it may contribute to inflammatory.

Preoperative immunonutritional indices are widely reported to predict survival after colorectal cancer (CRC) resection, yet their independence varies across cohorts and no data exist from the Arab.

BACKGROUND: Severe acute pancreatitis (SAP) is a life-threatening systemic inflammatory disorder with limited therapies. Recent evidence underscores the excessive formation of neutrophil.

Acute coronary syndrome (ACS) is strongly associated with inflammation, which contributes to plaque instability, thrombosis, and adverse cardiovascular outcomes. High-sensitivity C-reactive protein.

OBJECTIVE: Chronic cough (CC)-i.e., cough lasting for ≥ 8 weeks- is a common and burdensome symptom in asthma patients; however, its pathophysiological mechanisms and clinical relevance remain.

BACKGROUND: Type 2 (T2) biologics represent a promising treatment option for chronic obstructive pulmonary disease (COPD) patients with eosinophilic inflammation. OBJECTIVES: To evaluate the.

Dellon et al. anti-IL-4 receptor alpha dupilumab improved histologic and symptom outcomes in EoE.

Bleecker et al. anti-IL-5 receptor alpha benralizumab reduced exacerbations in severe eosinophilic asthma.

Ortega et al. MENSA trial of intravenous and subcutaneous mepolizumab in severe eosinophilic asthma.

Pavord et al. anti-IL-5 mepolizumab cut exacerbations in severe eosinophilic asthma.

Crawford et al. G-CSF reduced febrile neutropenia after chemotherapy.