Key Publications

Antineutrophil Cytoplasmic Antibodies: Integrating History, Pathogenesis, and Modern Diagnostics.. Radhakrishnan A, Saikia B, Sharma A et al.. Int J Rheum Dis 2026.

Early infiltration of ischemia-conditioned Tregs attenuates BBB damage via suppressing neutrophil extracellular traps in. Li H, Zhang X, Lu J et al.. Cell Rep 2026.

Eosinophil Peroxidase Activity is a Reliable and Resilient Biomarker for Eosinophilic Chronic Rhinosinusitis.. Caceres C, Marsh ED, Smith KA et al.. Int Forum Allergy Rhinol 2026.

Eosinophilic angiocentric fibrosis in paediatric IgG4-related disease.. Prasad R, Vijayvergia P, Khatkar M et al.. BMJ Case Rep 2026.

Assessment of fluorescence interference in the basophil activation test: a case of indocyanine green-induced anaphylaxis. Sakimura S, Kakehashi K, Watanabe M et al.. J Anesth 2026.

Basophils in the regulation of allergies and inflammatory disorders.. Miyake K, Homma A, Takasawa S et al.. Allergol Int 2026.

Continuous infusion of granulocyte colony-stimulating factor is associated with an advantage in neutrophil recovery in p. Wang YL, Chang TY, Chen SH et al.. Cancer Chemother Pharmacol 2026.

Recombinant Human Granulocyte Colony-stimulating Factor for Reproductive Failure: A Systematic Review and Meta-analysis.. Belarmino ÉLRD, Sobral DS, Cavalcante RPD et al.. JBRA Assist Reprod 2026.

Circulating granulocyte colony-stimulating factor as a sex-unbiased global marker of lung and colorectal cancer cachexia. Morena F, Schrems ER, Cabrera AR et al.. Exp Physiol 2026.

CXCL16-driven neutrophil extracellular traps promote osteoporosis in APP/PS1 mice by disrupting bone remodeling.. Chen R, Sun X, Wu T et al.. Bone 2026.

EasyQuant: An automated imaging-based tool for quantifying neutrophil extracellular traps (NETs).. Carlota R, Pascoal S, Zeelen C et al.. J Immunol Methods 2026.

Methotrexate Modulates Polymorphonuclear Neutrophil Function Through Reduced Chemotaxis and Increased LOX-1 Expression.. Wieke V, Kraus RF, Gruber MA et al.. Immun Inflamm Dis 2026.

Neutrophil Extracellular Traps Mediate in vitro and in vivo Degradation of α-Synuclein Amyloid Fibrils.. Cardim-Pires TR, Martins ADS, Guimarães FV et al.. J Inflamm Res 2026.

Not Just Th2: Eosinophil-Associated Proteomic Networks Reveal Fundamental Differences Between COPD and Asthma. Wu X, Fan J, Ding H et al.. Allergy 2026.

Switching from mepolizumab to benralizumab in eosinophilic granulomatosis with polyangiitis (EGPA). Cottu A, Mattioli I, Groh M et al.. Chest 2026.

[Comparative analysis of clinicopathological features of allergic fungal rhinosinusitis and eosinophilic mucin rhinosinu. Ma DL, Zhang Q, Gao YG et al.. Zhonghua Bing Li Xue Za Zhi 2026.

Sensitisation to Common Environmental Respiratory Allergens in Karachi. Hanif H, Anis S, Saeed S et al.. J Coll Physicians Surg Pak 2026.

Algorithms in Allergy: Diagnosis of Hypereosinophilic Syndromes, 2026 Update. Lefèvre G, Roufosse F, Emmi G et al.. Allergy 2026.

Correlation of Serum and Tissue Eosinophils and Immunoglobulin E with Disease Severity in Bullous Pemphigoid: A Prospect. Krishnamoorthy K, Rai R, Shanmugasundaram S. Indian Dermatol Online J 2026.

From nasal cytology to cellular endotyping: mast cell-eosinophil interactions and overlapping inflammation in allergic r. Gelardi M. Front Immunol 2026.

Elevated plasma eosinophil-derived neurotoxin is associated with echocardiographic pulmonary vascular involvement in sta. Hu X, Dong F, Song Q et al.. Front Med (Lausanne) 2026.

A Peripheral Blood Circular Ribonucleic Acid-Based Nomogram for Risk Stratification in Chronic Myeloid Leukemia. Bai Y, Li X, Wang Y et al.. Clin Lab 2026.

T cells in chronic spontaneous urticaria show skin-migratory capacity and endotype-specific differences. Hermann Lang SC, Seidel J, Sachsenberg S et al.. Allergol Int 2026.

IL-18-associated basophil and mast cell activation in sepsis. Wang J, Qin B, Zhang X et al.. Inflamm Res 2026.

Optimized In-House Basophil Activation Test for Pediatric Egg Allergy: Agreement with a Structured Composite Clinical Cl. Qu X, Wang L, Cai Y et al.. J Asthma Allergy 2026.

Predictive value of the albumin-bilirubin score for all-cause mortality in individuals with stroke: machine learning pre. Zhao H, Chen R, Zhang J et al.. J Stroke Cerebrovasc Dis 2026.

Under the Drapes: Unmasking the Mechanisms and Clinical Diagnosis of Perioperative Hypersensitivity. Ebo DG, Peeters L, Toscano A et al.. Curr Allergy Asthma Rep 2026.

Bioassays in Allergy: Technical Characteristics, Limitations, and Pathways to Clinical Implementation-An EAACI Position . Karaaslan C, Palomares O, Kilic B et al.. Clin Transl Allergy 2026.

Vespula spp. venom immunotherapy: basophil excitability and Fc(ε)RI/Fc(γ)RIIb expression. Fleissner J, Stoevesandt J, Goebeler M et al.. Allergy Asthma Clin Immunol 2026.

Loss of Tars induces proteostasis stress and drives HSPC exhaustion through mTORC1 activation. Li NZ, He MK, Wang Q et al.. Acta Pharmacol Sin 2026.

Immune responses induced by a subunit vaccine against Mycoplasma gallisepticum. Miller JM, Mara AB, Ozyck RG et al.. Infect Immun 2026.

CIDER: detecting changes in gene regulatory networks that are associated with changes in phenotype. Jung WJ, Ding M, Liao S et al.. bioRxiv 2026.

Clinical outcome and infectious complications in genetic and suspected genetic neutropenia: A report from the Canadian I. Choi YB, Alshammari NRR, Mathew R et al.. Br J Haematol 2026.

Development and temporal validation of preoperative and combined preoperative-pathological models for lymph node metasta. Zhang J, Cai L, Kong Y et al.. Front Oncol 2026.

Atypical Bullous Sweet Syndrome. London J, Patresan J, Belkin A et al.. R I Med J (2013) 2026.

ZDHHC5-mediated S-palmitoylation of NOD2 drives neutrophil extracellular trap formation via mitophagy to exacerbate infl. Dai Z, Chen X, Peng Y et al.. Biomark Res 2026.

Effects and mechanism of CYBB on the progression of multiple sclerosis: Evidence from bioinformatic analysis and experim. Lv M, Wei H, Zhao J et al.. Gene 2026.

Cytochrome P450 1A Protects against Hyperbaric Oxygen-Induced Lung Injury by Regulating Neutrophil Extracellular Trap Fo. You Y, Wang P, Huang J et al.. Chem Biol Interact 2026.

Histone neutralization protects the ischemic brain against the consequences of stroke-associated pneumonia. Yin D, Li A, Mohamud Yusuf A et al.. Acta Neuropathol 2026.

Obesity is a major independent risk factor for chronic kidney disease (CKD). Population-level evidence linking immune dysregulation to CKD in obese individuals remains limited. In this.

Candida albicans ( Calb ) in the lower respiratory tract (LRT) is considered a rare cause of pneumonia, yet its frequent recovery from LRT secretions of mechanically ventilated patients associates.

Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a redoubtable global pathogen, distinguished from classical K. pneumoniae (cKp) by its ability to cause life-threatening,.

BACKGROUND: Myeloperoxidase (MPO) and neutrophil elastase (NE) are key neutrophil enzymes involved in oxidative stress, inflammation, and neutrophil extracellular trap formation, all of which have.

Zhang J et al. review how NETs promote atherosclerotic plaque formation, thrombosis, and myocardial injury, and evaluate NET-targeting therapies including DNase and PAD4 inhibitors in cardiovascular settings. PMID: 42746070

Ascariasis is a prevalent parasitic infection in both humans and pigs, resulting in significant human morbidity and economic losses in the porcine industry. Experimental infections are often studied.

Veltri et al. map distinct eosinophil subsets by single-cell and spatial transcriptomics in a mouse asthma model.

BACKGROUND: Neutrophil extracellular trap (NET) formation (NETosis) has been proposed as a contributor to the pathophysiology of Long COVID (LC). However, it remains unclear whether markers of.

Wang N et al. develop a nanoparticle system that degrades NETs sequentially, first cutting DNA then removing granule proteins. In sepsis mouse models, sequential clearance reduces organ damage better than DNA-only DNase treatment. PMID: 42685208

Human ventricular biopsies show elevated NETosis in dilated cardiomyopathy; NETs co-localise with proinflammatory macrophages in myocardium. Neutrophil-macrophage crosstalk in cardiac failure.

LDNs from TB patients undergo ferroptosis and lose bactericidal capacity; iron-dependent cell death as a neutrophil immune evasion target in Mycobacterium tuberculosis infection.

BACKGROUND: The relationship between blood eosinophilia and length of hospital stay has been scarcely analyzed. OBJECTIVE: To establish the prevalence of eosinophilia in children with asthma.

Palisaded neutrophilic granulomatous dermatitis (PNGD) is an uncommon reactive granulomatous dermatosis frequently associated with rheumatoid arthritis (RA). Histopathologically, PNGD is.

Yu Q et al. show that neutrophil apoptotic bodies suppress osteoclastogenesis by interfering with TLR2-Siglec15 signaling, limiting bone loss during infection. Identifies a new anti-inflammatory role for late-stage neutrophil death. PMID: 42637734

Wang C et al. review how tumor-associated neutrophils (TANs) suppress anti-tumor immunity via arginase, ROS, and NET formation, and discuss therapeutic strategies to reprogram neutrophil phenotype. PMID: 42740960

Neonatal neutrophil functions mature at different rates; distinct stage-specific states shift from antimicrobial deficit to pro-resolution repair. Relevant to maturation sequence.

Zhou QX et al. review how neonatal neutrophils transition from immature immunodeficient cells at birth to progressively more pro-inflammatory states, with implications for sepsis and lung injury management. PMID: 42666783

Chen X et al. show that gout-associated monosodium urate crystals reprogram neutrophils and monocytes epigenetically, increasing inflammatory responses in subsequent encounters. PMID: 42656754

NETs in tumor-draining lymph nodes suppress NK cell surveillance via the CCDC25 receptor; mouse orthotopic breast cancer model. Extends NET biology to metastatic niche formation.

Heterophils, the avian equivalent of neutrophils, lack myeloperoxidase and use cathelicidins and defensins instead; comparative model for mammalian azurophilic granule biology.

Stojanovic B et al. review how eosinophils form extracellular traps (EETs) and the role of EETs in asthma, eosinophilic esophagitis, and parasitic infections. EETs differ from neutrophil NETs in granule composition and trigger signals. PMID: 42652123

CPB differentially regulates elastase release and NET formation; dissociates two effector programs both dependent on azurophilic granule contents.

Hamdan et al. review cell line, animal, and stem cell derived models used to study neutrophils.

Review: DNA methylation, histone modification, and ncRNA reprogramming alter neutrophil gene expression in sepsis; identifies candidate epigenetic biomarkers and therapeutic targets.

Wang S et al. link extracellular Ca2+ influx via ORAI1/STIM1 to mitochondrial reactive oxygen species and PAD4-driven NETosis. Blocking Ca2+ entry halts NET release, connecting ion channels to chromatin decondensation. PMID: 42476007

Han X et al. review evidence that eosinophils in allergic rhinitis not only release cytotoxic granule proteins but actively modulate T cell and innate lymphoid cell responses, acting as bidirectional regulators. PMID: 42488659

Neutrophil-lineage cells are generated in the marrow and participate in forming the pre-metastatic bone niche; reviews their trafficking and reprogramming.

Almas S and Lacy P review the four modes of eosinophil granule release: classical exocytosis, piecemeal degranulation, compound exocytosis, and cytolysis. Each mode has distinct trigger requirements and downstream effects. PMID: 42439685

Zhong WJ et al. identify NINJ1, a plasma membrane rupture protein, as required for NET release in acute lung injury. NINJ1 knockout mice form fewer NETs and have reduced lung inflammation. PMID: 42350381

Elrod R et al. show that IP G-CSF in NSG mice increases circulating neutrophil counts to human-range levels, validating a humanized model for neutrophil biology studies. PMID: 42278624

Single-cell RNA-seq of eosinophils, basophils, and neutrophils in atopic airway disease; maps granulocyte heterogeneity beyond bulk transcriptomics.

Dean LS et al. describe a spectral flow cytometry panel for simultaneously measuring neutrophil activation markers and NET formation, resolving populations not separable by conventional flow. PMID: 42376696

Zakrzewski P et al. show that neutrophil mitochondria sustain degranulation in sepsis. Mitochondrial inhibition reduces granule release and protects endothelium. Links energy metabolism directly to neutrophil effector output. PMID: 42204305

PMN-MDSCs identified by multi-omics; authors argue functional assays are still required because transcriptomic signatures do not reliably predict suppressive activity.

Wang F et al. review how MSU crystals trigger NET formation in gout, how NETs propagate joint inflammation, and the potential of NET-clearing agents to reduce flare severity and chronicity. PMID: 42212135

Neutrophils phagocytose adenovirus and respond with a pro-inflammatory program; characterises a poorly understood neutrophil-virus interaction.

OBJECTIVE: There has been limited research comparing the inflammatory characteristics of moderate and severe asthma in Brazil. To describe and compare the phenotypes of moderate asthma (MA) and.

Pires S et al. show that ILC3s activated by TL1A in colitis drive emergency granulopoiesis through IL-17 and G-CSF signals, linking intestinal inflammation to elevated circulating neutrophils and CRC risk. PMID: 41576959

van Grinsven et al. review why the neutrophil nucleus is lobed and what segmentation does for migration and function.

Gordon on Metchnikoff's discovery of phagocytosis and its place in immunology.

Kay on how Ehrlich's aniline dye staining defined the neutrophil, eosinophil, and basophil.

Martinod et al. PAD4-deficient mice form few NETs and are protected from deep vein thrombosis.

Voehringer review separating basophil and mast cell functions in host defense and allergy.

Kolaczkowska and Kubes review of the recruitment cascade, effector functions, and resolution.

Borregaard review of neutrophil production, granule populations and their mobilization, and killing mechanisms.

Pilsczek et al. describe rapid NET release in response to S. aureus by a route distinct from the slow lytic pathway.

Papayannopoulos et al. show elastase and MPO from azurophilic granules drive chromatin decondensation during NET formation.

Hakkim et al. found a subset of SLE patients whose serum fails to degrade NETs, associated with lupus nephritis.

Pillay et al. deuterium labeling in healthy volunteers gave a circulating neutrophil lifespan of 5.4 days, far longer than older estimates.

Rothenberg and Hogan review of eosinophil development, IL-5 and eotaxin biology, granule proteins, and eosinophilic disease.

Brinkmann et al. first description of NETs: extracellular chromatin with granule proteins that traps and kills bacteria.