Latest Research

USP48 stabilizes S100A9 in cancer cells to induce NET formation; NETs facilitate peritoneal metastasis in gastric cancer. Identifies a cancer-cell-to-neutrophil axis driving NET release.

Hair follicle lipidome in hidradenitis suppurativa shows arachidonic acid/LTB4 pathway activation and neutrophil NET formation in inflamed skin.

Melatonin reduces neutrophil recruitment and maturation to liver in a heatstroke model, limiting hepatic injury; mechanism involves single-cell transcriptomic characterization of the neutrophil response.

Aged neutrophils recruited to the tumor microenvironment suppress CD8+ T cell immunity through NET formation, driven by HMGB1 released by HCC cells.

Review of imaging strategies and therapeutic approaches to reprogram tumor-associated neutrophils (TANs) in precision oncology.

Neutrophils degrade the myoepithelial layer via elastase release, facilitating DCIS-to-invasive transition; elastase inhibition is proposed as a target.

Review links bacterial infection, NET formation, and MMP-9 activation in the pathogenesis of cholelithiasis.

Chen et al. review how NETs drive fibroblast activation and collagen deposition in pulmonary fibrosis.

Editorial introducing a research topic on NETs in the tumor microenvironment.

Zhou et al. review NETs in gastrointestinal cancer; single source.

Shahzad et al. review of NET roles across tumor types.

Systematic review and meta-analysis of NETs in IBD.

Macrophage-derived selenoprotein P (SELENOP) functions as a redox checkpoint in macrophage-neutrophil crosstalk during Crohn's disease. Neutrophil accumulation and oxidative injury are prominent features.

Gupta et al. editorial on where the normal blood eosinophil range should sit; opinion, not data.

Hu et al. review NETs from atherosclerosis through reperfusion injury in coronary heart disease.

Ma et al. show that sphingosine-1-phosphate via TREM2 protects immunosuppressive tumor-associated neutrophils from ferroptosis, sustaining HCC immune evasion.

Li et al. use Mendelian randomization to argue elevated neutrophil count causally raises endometriosis risk; single MR study, replication needed.

Shi et al. report chemotherapy-induced senescent hepatocytes trigger NETs that reawaken dormant pancreatic cancer cells in the liver.

Wang et al. propose clearing NETs in sequence as a sepsis therapy strategy.

Xie et al. report that persistent NETs cause fractures to fail to heal.

Xu et al. review NETs in colorectal cancer, from inflammation-driven tumor formation to liver metastasis.

Wang et al. review NETs across liver diseases.

Hu et al. review NETs as drivers of sepsis-induced coagulopathy.

Ebo et al. on reporting basophil activation test results when basophils do not respond.

Zhu et al. review NETs in CNS disease; human mechanistic evidence thin.

Middleton et al. NETs and immunothrombosis in COVID-19 ARDS.

Persson et al. Charcot-Leyden crystals of galectin-10 promote type 2 inflammation; antibodies dissolve them.

Netea et al. general review of innate immune memory; not specific to granulocytes.

Fridlender et al. propose TGF-beta driven N1 and N2 tumor-associated neutrophil states in mice; framework contested.